Headache Blog about conditions and treatments of headaches
In the last blog, I told the story of the development of monoclonal antibodies (mAbs) against CGRP, from their first appearance in the literature in 2007 to their licensing in the USA and Europe in 2018-19. In the third blog in this sequence I will go into a little more detail on the evidence for … Read more
In the last blog, I took the CGRP story from the 1980s to the 2000s, from the fortuitous discovery of triptans to advent of monoclonal antibody technology, and the first inklings that it could be applied to the treatment of migraine. Useful drugs do not always start out as such. One transformation, seen time and … Read more
For the last 150 years, the understanding of migraine has oscillated between two poles: the vascular theory (that migraine is a disease of blood vessels and blood flow), and the neural theory (that migraine is first and foremost a brain disease). The first generation of truly effective acute migraine treatments – ergotamine and DHE – … Read more
I am employed by Buckinghamshire Healthcare NHS Trust for 10.5 PA (42 hours) per week. In addition to that I am engaged in private practice at BMI The Chiltern Hospital and The Medical Chambers Kensington. I have received honoraria in the last 10 years for advisory boards and lecturing from Novartis, TEVA Pharmaceuticals, Lilly, and … Read more